Communication is increasingly becoming more and more critical in today’s society. Technology, in particular, has brought a whole new meaning to how we can communicate effectively with our loved ones and work from anywhere in the world. New powerful smartphone technology has allowed us to do more than ever before. The focus will shift more towards the ability to multitask and use the phone to its full potential rather than being limited by a small screen. Here are some new smartphones you should tune into if you are looking for one of the best new phones in 2023:
1. iPhone 14
Apple will never cease to amaze and impress us with the quality of its products. The new iPhone will be released early in 2023 and is said to be the most advanced phone developed by Apple. This phone will also come with a battery lasting approximately 22 hours. Compared to other smartphones, this is an incredible feat. The processor on this new phone is also high-speed and powerful, allowing you to quickly complete tasks without waiting for the device to load. The average price is about $700 USD.
2. Samsung Galaxy A74 5G
This new phone will be able to connect to a 5G network using a built-in adapter that will let any smartphone user get hours of uninterrupted video and video calling. Paired with ample internal storage and an enormous battery, this phone is perfect for keeping track of your business and personal life. This phone will come with four cameras that allow you to take incredible photos and videos using the newest technology and some of the best software. The average price is about $400 USD.
3. Sony Xperia 5 IV
This phone will have a 5G connectivity feature, making it one of the most advanced smartphones in 2023. This phone is perfect for businesses looking to make video calls without worrying about the network dropping. The camera allows you to snap amazing selfies and videos more efficiently than ever before. The powerful Qualcomm processor provides a faster and smoother interface when multitasking. This phone also comes with a battery that has a life of at least 12 hours. The average price is about $1000 USD.
4. Xiaomi 13 Pro
You need an excellent camera to capture those incredibly crisp photos and videos. This android device is among the best smartphones in 2023, with a whopping 48-megapixel primary camera. However, this is not all. This phone will be 4G compatible and have 6GB RAM. The 6GB RAM ensures you can continue working without worrying about your phone slowing down or freezing up when doing multipurpose work on the go. The powerful battery allows you to keep the phone running for at least 6 hours after charging it for 3 hours. The average price is about $1200 USD.
5. Huawei P60 Pro+
Huawei, one of the most profitable smartphone makers in the world, is known for making big phones. The P60 Pro+ is no different. Expected to be released in early 2023, this phone will be able to make all of your multitasking needs a breeze with its two screens. The P60 Pro+ will come with a 48-megapixel camera that allows you to take incredible selfies and videos without requiring additional equipment or too much space on your phone. The foldable screen will let you turn this phone into a tablet, even without removing the battery. The average price is $1500 USD.
Communication is now crucial in the modern world. From working with your clients to communicating with your loved ones, communication is something we cannot live without. Having the most advanced technology available is vital to ensure you can be connected to the world at all times. The future is bright for all of us, with excellent phones and top-of-the-line technology on the horizon.
Multiple sclerosis is a lifelong disease that requires various modalities of treatment. Plan of care considerations include (1) the patient’s age at onset of illness; (2) sex; (3) the extent of the disability at the time of diagnosis as well as (4) the form of multiple sclerosis. Treatment will be a multidisciplinary approach that involves specialists such as neurologists, rehabilitation specialists, neuro-urology experts, psychiatrists, occupational therapists, physiotherapists and social workers. This method is essential to ensure that all aspects of the disease are considered to help improve their quality of life.
The management of multiple sclerosis consists of a four-prong approach that involves: (1) management of acute exacerbations; (2) reduction of the frequency of relapses; (3) administration of the complications and (4) management of permanent disability that has already occurred. These are the goals of the management. No cure for the disease has been established.
High-dose steroids such as corticosteroids are the cornerstone of treating acute exacerbations because they reduce and control inflammation. Steroids are generally reserved for patients with exacerbations severe enough to cause functional disability or in those that exacerbations are prolonged beyond the duration of 24 hours. Corticosteroids work by reducing the inflammation which is a primary cause of the systems of multiple sclerosis. They work by binding to receptors on the cell surface and preventing the formation of various proteins. This, in turn, leads to inflammatory activity suppression. 2014 guidelines recommend pulsing with intravenous methylprednisone or methylprednisone given orally at doses of 500mg to a maximum of 1 g and 2 g respectively for a total of 3-5 days. The steroids can then be tapered off over two weeks or, be followed by a dose of prednisone 60-80 mg once a day which can be tapered off over two weeks.
Pulsing with high-dose steroids helps to reduce the severity of the acute attack as well as reduce the number of days of disability. However, their benefit in preventing future relapses or halting disease progression has not been shown. Their use is limited to a maximum of three times a year due to the multiple adverse effects that result from chronic steroid use. These include: osteoporosis, psychosis, mood lability, cataracts, gastritis, fluid retention, weight gain, Cushing’s syndrome, increased insulin resistance and increased the incidence of infections. Proton pump inhibitors such as esomeprazole have been used for prevention of gastritis especially in patients who report the incidence of peptic ulceration. Histamine receptor antagonists have also been used. Lithium, a mood stabilizer, has been used in the management of the mood disorders that result.
Plasmapheresis has also been used in the management of acute episodes where corticosteroids fail. Its wide use is limited by resources as it is quite expensive.
The relapsing-remitting form of multiple sclerosis is characterized by episodes of attacks followed by periods of disease remission. One of the goals of treating these patients is to prevent the relapses. Disease modifying drugs are used to achieve this. The two main drugs used are Glatiramer acetate and Interferon beta (IFN β). These two drugs should be initiated before permanent disability sets in because they have no effect on permanent neurological deficits. Four conditions need to be met before therapy with these agents can be started. They are: (1) the patient should be physically fit and able to walk for a substantial distance without assistance; (2) they should have a history of at least two severe relapses in the past 24 months; (3) they should be above 18 years and (4) they should have no contraindications to the use of the two drugs.
Interferon β belongs to a group of cytokines in the body called interferons. It is classified under Class 1 of that group. The two forms of interferon β have been found to be useful in the management of relapsing/remitting multiple sclerosis are as follows: interferon β 1a (Avonex and Rebif) and interferon β 1 b (Betaferon). The mechanism of action of these drugs involves reducing the frequency and severity of attacks by (1) lessen the manifestation of Major Histocompatibility Complexes (MHC) on the surface of antigen presenting cells; (2) inhibiting cytokines that favor inflammation and increasing those that regulate the levels of other cytokines; (3) reducing T-cell proliferation and (4) lessen the entry of inflammatory cells into the central nervous system.
Avonex is given as an intramuscular injection, 30 micrograms once per week. Rebif is given subcutaneously, 44 micrograms three times a week. Betaferon is also given subcutaneously, 250 micrograms every other day. Some of the common side effects of interferon therapy include skin reactions at the sites of injection causing necrosis; lipoatrophy due to the subcutaneous injections and flu-like symptoms like headaches, fever, fatigue and muscle aches.
Glatiramer acetate is an immunomodulatory drug that contains four amino acids: glutamic acid, lysine, alanine, and tyrosine. It has been shown to reduce the frequency of attacks in patients with relapsing- remitting form. The mechanism of action is not well elucidated, but various theories exist. Some of these theories suggest that glatiramer can facilitate the conversion of inflammatory T cells into non-inflammatory forms as well as act as a decoy since it has a similar structure to the myelin which is the target of the inflammation. It has however not been shown to influence the permeability of the blood-brain barrier as the interferons do. Glatiramer is given as a subcutaneous injection, 20 mg daily. Just like Interferon β, it causes injection site reactions.
Other drugs that have been used in the prevention of attack rate include Natalizumab, Fingolimod, Teriflunomide, Mitoxantrone Hydrochloride, Cladribine, Intravenous Immunoglobulins, Methotrexate, and Cyclophosphamide.
There’s just something about a classic pick up truck. As far as stature and power, the following trucks led the way as far as impressive styling, engine power, hauling and off road capabilities that, no doubt, inspired the design of many pickups on the road today.
Here’s our list of the six most tried and true pickup trucks in history:
When I was a kid, all the cool teens had a Ford Bronco, but those with a limited edition Baja Bronco were king of the road. Why? As far as off-roading capabilities, the Baja offered a powerful 302-cid V8 paired with a C4 automatic, plus drivers got a impressive boost due to the high cut rear wheel wells and flares, which left ample room for huge tires. The Baja screamed daring adventure roll cage and special enhancements made to offer heavy-duty suspension.
Ford longed to take their classic F150 off-road, but it took until 2009 for them to create the Raptor, a pick up that offered smooth driving and handling and four-wheeling on even the most extreme desert terrain. Not to mention, this truck could haul an 8000-pound trailer. No problem! Offered in a SuperCrew cab and SuperCab configuration, the Raptor also featured a 4WD system based on the standard F-150, plus urethane bump stops and internal-bypass Fox Racing shocks, which allowed for smooth-riding suspension over the roughest roads and highest jumps.
More of a conversion kit than a model truck, Napco (otherwise known as the Northwest Auto Parts Company) made up for the fact that 1950s pickups didn’t come in 4WD (opposed from Dodge). So Napco designed a 4WD offered a conversion kit that let Chevy, Fords, and GMC owners get the 4WD power they longed for. By the year 1957, pick up manufacturers finally caught on and began installing Napco Power-Pak 4WD conversions on their assembly line pick ups.
While GM and Ford enthusiasts may have issue with this truck, one can hardly match the ruggedness of the Dodge Ram of the early 90’s with it’s Cummins diesel engine. In fact, you can still witness the impact of this redesigned Ram on many GM and Ford trucks to this day, with it’s “big rig” styling.
Prior to the Ford F-150, the Highboy was king of the Ford pick up empire. A tough-as-nails truck renowned for it’s ultra-rugged driving capabilities on any terrain, the Highboy was named for its sky-high frame and 35-inch tall tires that was inches taller than any Jeep, Dodge, or GM on the market. After 1977, the Highboy was considered a “Lowboy” as it was constructed at least 2-inches lower, which is why the original pre-1977 model is now considered a collector’s item.
When a celebrity race car driver pairs up with an auto manufacturer, sometimes the results can be disappointing, which was sort of the case when Rod Hall collaborated with Chrysler to birth the Rod Hall Signature Edition Dodge pick up truck. Only 33 of these beauties were made, and despite the Dodge Ram 150 base design, bed-mount light bar and driving lights, and slick pre-runner front and rear bumpers, for some reason Dodge plopped in a whimpy 318-cid V8 with only 170 hp. Despite the fact, this truck continues to be a collector’s item among pick up truck buffs.
The pickup truck is synonymous with America. It’s tough. It works hard. And it has no problem getting dirty to get the job done. This is likely why the pickup truck continues to be among the best selling vehicle in North America. Regardless of if you’re part of team Dodge, Ford, or Chevy, you know that owning a truck offers a truly unique driving experience compared to any sedan, small compact, or even an SUV.
Here are our top reasons to super-size your driving experience to a pickup truck:
If it’s room you desire, ignore any desires to buy a sleek, compact car and turn to a pickup instead. Seriously, a recent Chevy Silverado offers ample legroom and cargo space for a comfortable daily commute or road trip because who wants a leg cramp to start the work day. Passengers can literally stretch their legs out in a roomy four full pickup truck with ample room for tools and everything you need.
Perhaps power and hauling capabilities are your biggest concern when thinking about pickup truck ownership. However, believe it or not safety is a huge benefit of pickup truck ownership. positive! Think about the safety features built in to most full-size trucks—you get a caged cab, vehicle stability, safety seatbelt systems, side impact protection, and even trailer sway control already built into your vehicle.
Sure, if you own a pickup truck you kind of open yourself up to helping every single person you know move house. However, when it comes to hauling your own stuff, you can’t go wrong with a pickup truck. Take a truck like the Chevy Silverado for example, you can suddenly haul up to 12,000 pounds no problem thanks to the impressive torque and horsepower. Suddenly your vehicle can easily transition from work truck to off road camping vehicle of your dreams.
If it’s a boost you want, a pickup is your best bet when it comes to the best visibility on the road. The height of a standard pickup truck cabin permits a view over most other vehicles on the highway. Is that a traffic jam 6 blocks ahead? Luckily, you’ll be able to see it and take a quick detour if you drive a pickup. Not to mention, the cab of a pick up offers the driver and all passengers all-round visibility, front, back and side thanks to huge rear and side-view mirrors.
Leading us into the next reason why trucks are such great vehicles.
Putting aside all jokes about overcompensating, there is little doubt that many individuals choose to drive a pickup for the sheer power it offers. While Ford, Chevy, and GM differ as far as horses under the hood, most current trucks offer between 350- to 440-horsepower (hp) if you consider a Ford F-250 or a Dodge Ram.
Pickup trucks represent the American dream. And while car buyers have vered from SUV to sports coupe over the past few years, pickup truck buffs tend to harken to the past when it comes to sticking with their love of the classic pickup truck. Many of the following classic trucks in good condition sell for a pretty steep price among collectors.
Here are four of the most coveted collectible pickup trucks:
Considered neither a car nor a truck, the Bronco was unique as far a broaching the needs of both a car and a truck driver, which explains it’s motto “the best of both worlds”. This cube shaped truck debuted for 1966 in rudimentary form for a mere $2400 (base model). However, it was the impressively wide (at 92-inches) wheelbase that offered serious off roading, smooth highway driving, and extreme towing capabilities in a single vehicle. Touted literally as a sports car with 4-wheel drive, the Bronco was mounted on coil springs and outfitted with a V8 engine that could literally take drivers from camping to off roading while offering the style and comfort of a family wagon. Today, this year range of Ford Bronco retails for $25k plus.
Behold the inaugural Ford F-series pickup. Think of it as the crown of America’s trucking obsession. Considering this Ford series has ranked in the best-selling for decades, many pickup truck owners are still firmly planted in the Ford camp thanks to this very vehicle. If you’re lucky enough to find a 1948 Ford F1 for sale, you can expect to pay upwards of $30K depending on condition and customizations.
Looking at this truck, there’s little wonder that it was originally designed in the early 1940’s for military purposes. However, the Dodge Power Wagon caught on in the mainstream market due to its ability to travel virtually anywhere. The impressive 4×4 capabilities of this truck was so good that it there were no revisions until it was discontinued in 1968. If you spot one, expect to pay $45k or more!
It was called the “Super” for good reason. This high-option, everyday use pickup truck boosted unique interior design with a/c, tach dash, power brakes and steering, headliners, and tilt columns. Plus, the exterior could be costoumize with special paint and trim. Find one and expect to pay up to $30k for a model in good condition with lots of options.