What do you buy the man in your life that has everything? To make gift giving even easier on you, look into subscription boxes! Subscription boxes are essentially recurring deliveries/packages of selected interest based products. They are typically used by e-commerce businesses as part of a marketing strategy or method of distribution. Currently, it is estimated that there are around 400 to 600 of these subscription boxes around the US.
Clothing subscription boxes are a good way to keep things simple yet creative. Here are six of the best rated clothing subscription boxes for men:
1. Frank and Oak Style Plan for Men
Frank and Oak Style Plan for Men is a great option. Every month, stylists and website algorithms choose a style for you. After that, you preview and customize your order. Then, take 30 days to decide what you want and send the rest back for free. Simple! The plus about this option is that there is no monthly fee and affordable.
2. Menlo Club
Here is another option for subscription boxes for men that provides clothing, shoes and accessories for men. It is only $60 a month and you can receive 2 or 3 things based on your preference.
3. Stitch Fix Men
Stitch Fix allows you to take a style quiz to see what clothing fits you best. You pay a $20 fee which goes towards your items. You try on what you want and send the rest free of charge. Another feature of this subscription box is that it requires no subscription.
4. Bespoke Post
Like many other sites, this company follows a similar model: take a style quiz, pay a small fee (in which case it’s $45), try the things you like and send it back for free). The website is easily navigable and allows you to get a solid feel on what they have to offer (what to expect).
5. Gentleman’s Box
The Gentleman’s Box is a more popular brand that some are familiar with. Not only do they help with your style, they assist with your LIFEstyle. They promote health, community and fashion. With two options, you can choose between a premier or classic subscription. The options this site offers are pretty wide ranged and quality. They even offer luxury goods! With that being said, it is a fair deal being only $29 a month for 4-6 fashion and lifestyle accessories.
Last on the list is Sprezzabox! With over 300,000 members and only $29 a month you can receive curated classy goods. Although boxes are customized, this particular brand is geared toward a more suit and tie aesthetic. There isn’t much casual wear on the site, but that could be a plus depending on the style of your choice.
Regardless of the subscription box you choose, it is a good gift to consider for men. Even if not for a gift, this is a great way to save money while curating your style!
Multiple sclerosis is a lifelong disease that requires various modalities of treatment. Plan of care considerations include (1) the patient’s age at onset of illness; (2) sex; (3) the extent of the disability at the time of diagnosis as well as (4) the form of multiple sclerosis. Treatment will be a multidisciplinary approach that involves specialists such as neurologists, rehabilitation specialists, neuro-urology experts, psychiatrists, occupational therapists, physiotherapists and social workers. This method is essential to ensure that all aspects of the disease are considered to help improve their quality of life.
The management of multiple sclerosis consists of a four-prong approach that involves: (1) management of acute exacerbations; (2) reduction of the frequency of relapses; (3) administration of the complications and (4) management of permanent disability that has already occurred. These are the goals of the management. No cure for the disease has been established.
High-dose steroids such as corticosteroids are the cornerstone of treating acute exacerbations because they reduce and control inflammation. Steroids are generally reserved for patients with exacerbations severe enough to cause functional disability or in those that exacerbations are prolonged beyond the duration of 24 hours. Corticosteroids work by reducing the inflammation which is a primary cause of the systems of multiple sclerosis. They work by binding to receptors on the cell surface and preventing the formation of various proteins. This, in turn, leads to inflammatory activity suppression. 2014 guidelines recommend pulsing with intravenous methylprednisone or methylprednisone given orally at doses of 500mg to a maximum of 1 g and 2 g respectively for a total of 3-5 days. The steroids can then be tapered off over two weeks or, be followed by a dose of prednisone 60-80 mg once a day which can be tapered off over two weeks.
Pulsing with high-dose steroids helps to reduce the severity of the acute attack as well as reduce the number of days of disability. However, their benefit in preventing future relapses or halting disease progression has not been shown. Their use is limited to a maximum of three times a year due to the multiple adverse effects that result from chronic steroid use. These include: osteoporosis, psychosis, mood lability, cataracts, gastritis, fluid retention, weight gain, Cushing’s syndrome, increased insulin resistance and increased the incidence of infections. Proton pump inhibitors such as esomeprazole have been used for prevention of gastritis especially in patients who report the incidence of peptic ulceration. Histamine receptor antagonists have also been used. Lithium, a mood stabilizer, has been used in the management of the mood disorders that result.
Plasmapheresis has also been used in the management of acute episodes where corticosteroids fail. Its wide use is limited by resources as it is quite expensive.
The relapsing-remitting form of multiple sclerosis is characterized by episodes of attacks followed by periods of disease remission. One of the goals of treating these patients is to prevent the relapses. Disease modifying drugs are used to achieve this. The two main drugs used are Glatiramer acetate and Interferon beta (IFN β). These two drugs should be initiated before permanent disability sets in because they have no effect on permanent neurological deficits. Four conditions need to be met before therapy with these agents can be started. They are: (1) the patient should be physically fit and able to walk for a substantial distance without assistance; (2) they should have a history of at least two severe relapses in the past 24 months; (3) they should be above 18 years and (4) they should have no contraindications to the use of the two drugs.
Interferon β belongs to a group of cytokines in the body called interferons. It is classified under Class 1 of that group. The two forms of interferon β have been found to be useful in the management of relapsing/remitting multiple sclerosis are as follows: interferon β 1a (Avonex and Rebif) and interferon β 1 b (Betaferon). The mechanism of action of these drugs involves reducing the frequency and severity of attacks by (1) lessen the manifestation of Major Histocompatibility Complexes (MHC) on the surface of antigen presenting cells; (2) inhibiting cytokines that favor inflammation and increasing those that regulate the levels of other cytokines; (3) reducing T-cell proliferation and (4) lessen the entry of inflammatory cells into the central nervous system.
Avonex is given as an intramuscular injection, 30 micrograms once per week. Rebif is given subcutaneously, 44 micrograms three times a week. Betaferon is also given subcutaneously, 250 micrograms every other day. Some of the common side effects of interferon therapy include skin reactions at the sites of injection causing necrosis; lipoatrophy due to the subcutaneous injections and flu-like symptoms like headaches, fever, fatigue and muscle aches.
Glatiramer acetate is an immunomodulatory drug that contains four amino acids: glutamic acid, lysine, alanine, and tyrosine. It has been shown to reduce the frequency of attacks in patients with relapsing- remitting form. The mechanism of action is not well elucidated, but various theories exist. Some of these theories suggest that glatiramer can facilitate the conversion of inflammatory T cells into non-inflammatory forms as well as act as a decoy since it has a similar structure to the myelin which is the target of the inflammation. It has however not been shown to influence the permeability of the blood-brain barrier as the interferons do. Glatiramer is given as a subcutaneous injection, 20 mg daily. Just like Interferon β, it causes injection site reactions.
Other drugs that have been used in the prevention of attack rate include Natalizumab, Fingolimod, Teriflunomide, Mitoxantrone Hydrochloride, Cladribine, Intravenous Immunoglobulins, Methotrexate, and Cyclophosphamide.
Communication is increasingly becoming more and more critical in today’s society. Technology, in particular, has brought a whole new meaning to how we can communicate effectively with our loved ones and work from anywhere in the world. New powerful smartphone technology has allowed us to do more than ever before. The focus will shift more towards the ability to multitask and use the phone to its full potential rather than being limited by a small screen. Here are some new smartphones you should tune into if you are looking for one of the best new phones in 2023:
1. iPhone 14
Apple will never cease to amaze and impress us with the quality of its products. The new iPhone will be released early in 2023 and is said to be the most advanced phone developed by Apple. This phone will also come with a battery lasting approximately 22 hours. Compared to other smartphones, this is an incredible feat. The processor on this new phone is also high-speed and powerful, allowing you to quickly complete tasks without waiting for the device to load. The average price is about $700 USD.
2. Samsung Galaxy A74 5G
This new phone will be able to connect to a 5G network using a built-in adapter that will let any smartphone user get hours of uninterrupted video and video calling. Paired with ample internal storage and an enormous battery, this phone is perfect for keeping track of your business and personal life. This phone will come with four cameras that allow you to take incredible photos and videos using the newest technology and some of the best software. The average price is about $400 USD.
3. Sony Xperia 5 IV
This phone will have a 5G connectivity feature, making it one of the most advanced smartphones in 2023. This phone is perfect for businesses looking to make video calls without worrying about the network dropping. The camera allows you to snap amazing selfies and videos more efficiently than ever before. The powerful Qualcomm processor provides a faster and smoother interface when multitasking. This phone also comes with a battery that has a life of at least 12 hours. The average price is about $1000 USD.
4. Xiaomi 13 Pro
You need an excellent camera to capture those incredibly crisp photos and videos. This android device is among the best smartphones in 2023, with a whopping 48-megapixel primary camera. However, this is not all. This phone will be 4G compatible and have 6GB RAM. The 6GB RAM ensures you can continue working without worrying about your phone slowing down or freezing up when doing multipurpose work on the go. The powerful battery allows you to keep the phone running for at least 6 hours after charging it for 3 hours. The average price is about $1200 USD.
5. Huawei P60 Pro+
Huawei, one of the most profitable smartphone makers in the world, is known for making big phones. The P60 Pro+ is no different. Expected to be released in early 2023, this phone will be able to make all of your multitasking needs a breeze with its two screens. The P60 Pro+ will come with a 48-megapixel camera that allows you to take incredible selfies and videos without requiring additional equipment or too much space on your phone. The foldable screen will let you turn this phone into a tablet, even without removing the battery. The average price is $1500 USD.
Communication is now crucial in the modern world. From working with your clients to communicating with your loved ones, communication is something we cannot live without. Having the most advanced technology available is vital to ensure you can be connected to the world at all times. The future is bright for all of us, with excellent phones and top-of-the-line technology on the horizon.
You need a new phone in 2021 and want the most innovative specs at an economical price. However, you’re unsure about which brand or model based on the overwhelming number of features and benefits. Start by considering your unique user needs first, and then take a look at these top six models listed below. Each has a ranking based on its cost-efficiency, specifications, and advantages:
1. Moto G Power by Motorola
Motorola produced two models of the moto g power smartphone, including the 32GB and the 64GB. These cell phones are available in eye-catching colors, such as the flashy grey and polarized silver. You will experience a long battery life up to three days without having to recharge your new phone. Its 6.6-inch HD-plus display is an ultra-wide screen for quality visual performance while gaming, browsing the internet, and watching videos or your favorite movies. The retail cost ranges from $199 and higher for the 32GB model and may be as low as $129 at some retailers and carriers
2. TCL 10L
Second on the list of the top six smartphones worth the money is the TCL 10L, which comes in arctic white or mariana blue. It has a sleek design that includes a 6.53-inch FHD-plus display and customized interface by TCL. Its octa core processor provides users with a smooth performance experience and 6GB of RAM. You will receive 4,000 mAh in a long-lasting battery to stream your favorite videos and movies before the need to recharge. Consumers can find this smartphone on sale as low as $200 and at a retail cost of $300 and up
3. LG Stylo 6
The LG Stylo 6 is available at various retailers and carriers for a sale price of $150 and a retail cost of $220. It is great for taking selfies with its 13MP camera that produces quality and picture-perfect photographs. The Stylo 6 features 64GB internal storage, 6.8-inch display, dual speakers, 4,000 mAh battery, and a 720-G processor. A stylus built-in pen comes with the smartphone for screen touching and writing
4. Redmi Note 9S by Xiaomi
Xiaomi Redmi Note 9S is an affordable smartphone model that has a sale price of about $175 and a retail cost of $274 and higher. You can find this cell phone in blue, white, or grey that features a built-in lithium ion polymer 5020 mAh battery for hours of usage listening to music, browsing the internet and watching videos. It has rear and front cameras and includes high-security technology using a fingerprint sensor and artificial intelligence facial unlocking features
5. Galaxy S21 by Samsung
Samsung Galaxy S21 includes models ultra 5G, Plus 5G, and the 5G in beautiful violet, white, pink, or grey coloration. Consumers can find these models at various carriers for a sale price of $74 and retail cost of approximately $800. Users will receive a 64MP sensor for clear photographs and an 8K video with quality resolution. The screen sizes are available in 6.8 inches, 6.7 inches, and 6.2 inches, depending on the model
6. Apple iPhone 12 Pro Max
The iPhone 12 Pro Max by Apple is the most expensive phone of all the smartphones that made the top six list. It can cost from $1,100 to $1,200, but is worth the money considering its features and benefits. This smartphone has a 6.7-inch HDR display screen, curved design, powerful 12MP camera system, panorama, and high-technology security. It is water, dust, and splash resistant because of its stainless steel and textured matte glass material for added protection
If you are looking for smartphones worth the money, the six brands and models listed are the best selections. Consumers can find valuable deals at their local carriers or online retail stores.
Each year advancements in technology bring new laptops packed with features previously impossible. That’s certainly the case with AMD after its commanding performance last year. With their powerful Ryzen 4000 laptop processors, AMD gives Intel some serious competition. The consumer electronics show 2021 showcased Microsoft, Dell, Lenovo, and several other manufacturer offerings, which blended the laptop into a professional and personal machine.
Here is a list of the best-rated laptops you should consider for your next purchase. Check your local Best Buy for the best laptop deals and pricing
1. Microsoft Surface Pro X
The Surface Pro X is an innovative design from Microsoft that is a 2 in 1 laptop tablet. Use it as a regular laptop or remove the screen for a large tablet on the go. With a starting price of $999, you get 8 GB of RAM and 128 GB of storage space. The Surface Pro X comes with Microsoft SQ1 or SQ2 chipsets (depending upon model) and features Microsoft’s thinnest form factor. The screen is 13” with almost no visible frame and offers up to 15 hours of battery life
2. Lenovo ThinkPad X1 Carbon
The ThinkPad X1 Carbon offers several features that help it make the list. First, it has a 14” screen but remains lightweight and thin. Battery life can last up to 19.5 hours and comes with a rapid rechargeability that provides around 80% battery life after one hour of charging. This model also can wake from sleep in less than a second giving you quick responsiveness. Additional connectivity with Wi-Fi 6 provides speedy and secure connections
3. Dell XPS 13
Dell has created the XPS 13 and certainly looks to generate competition for laptop manufacturers in 2021. The XPS offers a case professionally sculpted by a CNC machining process. This case provides an incredibly durable option with aluminum materials instead of magnesium or plastic. Sticking with the rugged theme, the XPS 13 also includes Gorilla Glass 6, which allows the screen to shrug off impacts and scratches. Finally, the unit is thinner than previous models but still retains the headphone jack and microSD
4. Apple MacBook Air M1
Apple has shown up to challenge its rivals with increased performance power. The M1 chip has given the MacBook Air a genuine performance boost over previous models. Not only is the M1 chip impressive, but the 8-core processor allows for extreme multitasking with minimal battery loss. MacBook Air uses a fanless cooling method in another unique design choice, which makes for silent operation
5. Acer Aspire 5
For multi-taskers and gamers, the Acer Aspire has some additional benefits with your choice of options under the hood. You can select either Intel or AMD processors and for graphics, either Nvidia or AMD. With the option for a 1 TB SSD drive, this model offers fast performance from boot-up to running simultaneous applications. The display is a Full HD IPS that incorporates stunning color depth and eye saving technology